In single infection, no differences in ToS-A accumulation were observed for the wt ToSRV, ToSRV-A(ToR:CR), ToSRV-A(ToR:IRD) and ToSRV-A(ToR:CR+IRD) treatments (Figure 3A), confirming that all three mutant ToSRV DNA-A clones are capable of replicating at equivalent wt levels. This evidence concerns the gene RORC and infection.