Esteso and colleagues [97] observed an increased shedding of the NKG2D ligand MICA post infection related to several strains of HCMV and due to an enhanced activity of ADAM17 (TNF-α converting enzyme) and matrix metalloprotease 14, advocated by a critical decrease in the expression of the endogenous inhibitor of metalloprotease tissue inhibitors of metalloproteinase TIMP3. The gene discussed is MICA; the disease is infection.