To evaluate the IL-6-inducing activity of the patients’ sera, as described previously [42], heat-inactivated serum samples collected from 130 (66 mild, 46 moderate, and 18 severe) COVID-19 patients at the time of diagnosis (Day 1) were incubated with and without the N protein to clarify the extent of IL-6 enhancement. This evidence concerns the gene IL6 and COVID-19.