They suppress the hyperactivation of dsRNA sensors (such as PKR, RIG-I/MDA5 (melanoma differentiation-associated protein 5), OAS (2′-5′-oligoadenylate synthetase)/RNase L, and ZBP1 (Z-DNA-binding protein 1, also known as DNA-dependent activator of IFN-regulatory factors (DAI)) that could lead to autoimmunity (reviewed in [4,5,6]). The gene discussed is ZBP1; the disease is Autoimmunity.