In vitro restimulation of monocytes isolated from RSV-infected patients with bronchiolitis (ex vivo) showed an increase in IL-10, associated with recurrent wheezing, and decreased levels of IFN-γ, IL-12, and IL-4, indicating a direct contribution of monocytes to immunosuppression during severe infections (Figure 3) [167]. The gene discussed is IL4; the disease is infection.