Inflammatory cytokines compromise the unfolded protein response (UPR) function through mortality factor (MORF)-mediated protein kinase-like endoplasmic reticulum kinase (PERK) transcription, which contributes to impaired endoplasmic reticulum (ER) function, prolonged ER stress, and defective osteogenic differentiation of periodontal ligament stem cells (PDLSCs) in periodontitis-associated chronic inflammation [13,14,15,16]. Here, EIF2AK3 is linked to periodontitis.