TNF and neoplasm: This study demonstrated a synergistic chemotherapy/photodynamic therapy/immunotherapy co-delivery platform with few side effects, which upregulated the expression of pro-inflammatory cytokines such as TNF-α, IL-6, and INF-γ in 4T1 tumor-bearing mice and promoted the M1 polarization of macrophages, effectively promoting tumor cell apoptosis and inhibiting tumor metastasis.