SIM2 and endothelial dysfunction: Nonetheless, in line with the improvement in PP reduction, the p-eNOS/eNOS ratio was significantly elevated by FPM-CD32b-Sim and mixed-FPM-Sim, suggesting an amelioration of endothelial dysfunction by stimulating nitric oxide production through the targeted release of simvastatin into LSECs of TAA-induced cirrhotic rats.