TLR4 and hepatocellular carcinoma: Thus, the expression levels of TLR4 and its associated proteins in HCC tumors could serve as prognostic factors for patients undergoing post-RT surgery, while the inhibition of TLR4, VEGFR2, and TRAIL expression in HCC and non-tumor liver tissue could potentially reduce the severity of RILDs and improve survival outcomes in the future [97].