TLR4 and hepatocellular carcinoma: Androutsakos et al., in a single-center cohort study, investigated the association of TLR4 SNPs (a transition at SNP rs4986790 resulting in an Asp/Gly polymorphism at amino acid 299 and a transition at SNP rs4986791 resulting in a Thr/Ile polymorphism at amino acid 399) with HCC occurrence and all-cause and liver-related mortality, as well as the time between the diagnosis of cirrhosis and HCC development or the diagnosis of HCC and death [84].