A study carried out by Cheng and collaborators (2023) [27] using HG–MNs based on methacrylated hyaluronic for delivery of acid estrogen receptor alpha (ERα)-degrading PROTAC-ERD308 and palbociclib within micelles responsive to tumor acid pH was developed for effective treatment of ER-positive breast cancer. The gene discussed is ESR1; the disease is breast carcinoma.