CD8A and neoplasm: On the other hand, dying cancer cells have to be antigenic to enable the induction of antigen-specific anti-tumor immunity [9,10] associated with the effective cross-presentation of immunogenic peptides on major histocompatibility complex class I (MHC I) to CD8+ T cells, which play a key role in the anti-tumor response [7,9] and the formation of long-term immunological memory [7,9].