For example, in non-pregnant women with acute pyelonephritis, the plasma concentrations of the pro-inflammatory cytokines IL-6 and IL-8, TNF-α, and protein C reactive (CRP) [15,16,17] can reach from 2 to 75 times the concentrations in healthy pregnant and non-pregnant women [15,16,17]. The gene discussed is IL6; the disease is acute pyelonephritis.