For example, oxamate, a structural analog of pyruvate, is a competitive inhibitor of both LDH-A and LDH-B, and it has been the subject of numerous studies that have shown interesting anticancer effects on various cancer cell lines, including those obtained from HCC, breast cancer, CRC, lymphoma, medulloblastoma, and ovarian cancer [30,31,32,33,34,35]. This evidence concerns the gene LDHA and cancer.