In the present study, we perorally treated microbiota-depleted IL-10−/− mice with menthol and the extracts from tormentil, raspberry leaves, and loosestrife from day 2 until 6 following C. jejuni infection and monitored the (i) pathogen loads in the gastrointestinal tract and extra-intestinal organs and assessed the (ii) clinical signs as well as (iii) intestinal and (iv) extra-intestinal immune responses during acute campylobacteriosis. This evidence concerns the gene IL10 and campylobacteriosis.