Interestingly, ellagic acids that are contained in extracts from the Lythraceae and Rosaceae families, with loosestrife herb and raspberry leaves being respective family members [72], have been shown to decrease expression of pro-inflammatory cytokines such as TNF-α and IL-6 in a TLR-4 dependent manner when applied in murine colitis [73]. The gene discussed is TLR4; the disease is colitis.