TNF and rheumatoid arthritis: Likewise, some therapies focus on the neutralization of mediator molecules (such as tumor necrosis factor-alpha (TNF), vascular endothelial growth factor (VEGF) and different interleukins (ILs)) or pathogens (such as B. anthracis), but it is well documented that Fc-dependent effector functions also have some advantages in the disease control of rheumatoid arthritis or in anthrax animal models [26].