Likewise, a fully controlled response may be associated, for instance, with the counteraction of tumor-induced cachexia and the inhibition of catabolic pathways (IL-6, TNF-alpha) balanced with the stimulation of anabolic pathways (FoxO3a, p-AKT, p-mTOR, and P-GSK-3β) [42]. This evidence concerns the gene TNF and neoplasm.