Further characterization and mechanistic studies on these novel analogs and their targets might offer novel and effective pharmacological interventions for diverse neurodegenerative diseases —Alzheimer’s and Parkinson’s diseases, amyotrophic lateral sclerosis, etc. Hyperphosphorylation of “off-target” protein targets, by GSK3β and other kinases, contributes to protein misfolding and aggregation that are strongly associated with a wide variety of neurodegenerative diseases. Here, GSK3B is linked to amyotrophic lateral sclerosis.