MAPT and Alzheimer disease: These novel small molecules reduce the aggregate burden in a variety of aggregation-model systems, including two human cell-culture models of AD: SY5Y-APPSw neuroblastoma cells (which express APPSw and thus promote accumulation of extracellular amyloid) and HEK-tau embryonal kidney cells that have neuronal properties (expression of neurofilament proteins) and also express a tau transgene to form paired-helical filament inclusions (tau tangles).