Although several non-pharmacological interventions (e.g., intake of dietary supplements including polyunsaturated ω-3 fatty acids) have been suggested to delay or reduce the severity of AD, further studies indicated that the protective benefits of such supplements were confounded by other dietary factors, the stage of AD, and the apolipoprotein E genotype [32,33,34,35,36]. This evidence concerns the gene APOE and Alzheimer disease.