Immune checkpoint blockade by targeting the programmed death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) pathway has demonstrated remarkable effectiveness in treating different types of cancer, such as melanoma, non-small cell lung cancer, renal cell carcinoma, and bladder cancer [1,2,3,4,5,6,7]. This evidence concerns the gene PDCD1 and hereditary clear cell renal cell carcinoma.