In addition, results from the negative control study revealed that the uptake of [68Ga]BMSH in A549-hPDL1 tumors was 1.9 times that in A549 tumors (4.22 ± 0.65%ID/g vs. 2.23 ± 0.41% ID/g, at 2 h post-injection, p < 0.01), while the biodistribution in the normal organs of A549-hPDL1 and A549 tumor-bearing mice was similar. Here, CD274 is linked to neoplasm.