In adult male rats subjected to in vivo regional myocardial ischemia (25 min) and reperfusion (120 min), treatment with the A1R-selective agonist 2-chloro-N6-cyclopentyladenosine (CCPA) (10 μg/kg) or the nonselective AR agonist 5′-N-Ethylcarboxamidoadenosine (NECA) (10 μg/kg) reduced myocardial infarction size by 50% and 35%, respectively [28]. The gene discussed is AR; the disease is myocardial infarction.