ATP2A3 and ischemia: ATP deficit during ischemia inhibits ATP-dependent ionic transporters, like Na+/K+-ATPase, Ca2+-ATPase plasmalemmal (PMCA), and sarco-endoplasmic reticulum Ca2+-ATPase (SERCA), leading to the accumulation of Na+ and Ca2+ in the cytosol [6,14] and cytosolic Ca2+ overload [6,14].