In addition, the possible modulatory effect of SV on the Phosphoinositide 3-kinases (PI3K)/Hypoxia-inducible factor 1-alpha (HIF-1α)/c-MYC/Nitric oxide synthase (iNOS) pathway involved in NDEA-induced HCC fibrinogen, together with the possible interrelation with the coagulation system activation marker, was also demonstrated. This evidence concerns the gene NOS2 and hepatocellular carcinoma.