In ER-positive cells, in addition to reducing cell viability, coumestrol significantly reduces the expression of genes that drive epithelial-to-mesenchymal transition (Snail), bone fixation (CXCR4 and integrin αV), and osteolysis (PTHrP and TNF-α) [344] Likewise, 4′-metoxicumestrol (25) is also cited as a phytoestrogen with an antiproliferative effect on luminal BC cells, downregulating Akt phosphorylation [242]. Here, AKT1 is linked to breast cancer.