NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome could be activated by microbial infection, stress or toxic substances which could interact with apoptosis-associated speck-like protein containing a CARD (PYCARD), and PYCARD played crucial roles in host defense and inflammation, which was associated with the pathogenesis of IBD [7,8]. Here, PYCARD is linked to inflammatory bowel disease.