Additionally, the combination of cisplatin and PAW in drinking water extended survival time in lung cancer mice-implanted LCC-1 cells compared to the combination of cisplatin and deionized water, and the possible mechanisms could be associated with the anti-inflammatory and antioxidant properties of PAW, which was proven by inducing nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant gene in human gingival fibroblasts [18]. Here, NFE2L2 is linked to lung cancer.