We found a ratio of 1:3 and 1:6 with naïve-MSC, sTRAIL-MSC, and flTRAIL-MSC-induced cell death and apoptosis against tumor cells (Caco-2 and CMT-93) that had moderate resistance to recombinant TRAIL which was statistically different from the negative control. Here, TNFSF10 is linked to neoplasm.