IL4 and skin disorder: Studies have shown that JTE-013 participates in the acute immune response, reduces the levels of histamine, inflammatory factors IL-4, IL-13, IL-17, and IFN-γ in mice, reduces the maturation and migration of dendritic cells, and participates in the degranulation of mast cells, which is involved in dermatitis [49] and asthma [15,40].