Similar to the results of siRNA-mediated knockdown of YAP, exposure to VP reduced both the transcription and protein expression of YAP (Figure 6A), while significantly inhibiting RA-FLS cell invasion and migration (Figure 6B,C) and the transcription levels of MMP1, MMP3, IL-6, and IL-1β (Figure 6D), which were all enhanced by TNF-α stimulation. This evidence concerns the gene MMP3 and rheumatoid arthritis.