The crosstalk between uPAR signaling and cancer pathways could be illustrated through kinase signaling (i.e., RTKs and RSKs) and intracellular cancer signal pathways, such as MAPK and PI3K-AKT pathways, to communicate and to affect cellular phenotypes (i.e., cancer hallmarks) during tumorigenesis and progression. The gene discussed is PLAUR; the disease is cancer.