SMAD4 and cancer: Network analysis results showed that 13 cancer driver targets (i.e., KRAS, ERBB3, EGFR, HRAS, MYC, SMAD4, AKT1, PIK3R1, JAK1, ATR, MECOM, RHOB and FGFR2) interacted with more than 90 compounds, forming the core of this cancerous uPAR signaling system, whose average node degree was 5.38.