By using the data of these real modulators to reconstruct the uPAR signaling network for comparison, it was found that the reconstructed network based on nine modulators (Table 2) could interact with 8 out of 10 above-mentioned cancer pathways, including MAPK, PI3K-Akt, mTOR, focal adhesion, cell cycle, VEGF, HIF-1 and apoptosis signaling pathways (Figure 3), suggesting that our approach unbiasedly revealed the tangling essences between uPAR and cancer signaling systems. The gene discussed is PLAUR; the disease is cancer.