Therefore, we evaluated the effects of compound JR19 on the production of pro-inflammatory cytokines (TNF-α, IL-2, IFN-γ, IL-6, and IL-17), which play a crucial role in leukocyte recruitment, as well as the anti-inflammatory cytokine (IL-4) in the carrageenan-induced peritonitis model in the presence or absence of L-NAME or methylene blue. This evidence concerns the gene TNF and peritonitis.