In the group of OI patients harboring mutations in COL1A1, upregulated expression of miR-17-5p, miR-21-5p, miR-26b-3p, miR27a-3p, miR27b-3p, miR29a-3p, mir29c-3p, miR-30a-5p, miR-34a-5p, miR-92a-3p, and miR143-3p was found. This evidence concerns the gene COL1A1 and osteogenesis imperfecta.