It is known that stress causes changes that may favor the development of depression [5]; stress is an important physiological response so that when exposure is high, hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA) occurs [6], which stimulates the paraventricular nucleus of the hypothalamus to release corticotropins, which in turn promotes the production of adrenocorticotropic hormone that acts on the adrenal gland and allows the release of cortisol, which is the main stress response hormone and acts on numerous glucocorticoid receptors [7,8]. The gene discussed is POMC; the disease is major depressive disorder.