BDNF and major depressive disorder: According to their research, resveratrol has good potential for the regulation of 5-HT1A-dependence in the brain–gut axis: cAMP-dependent protein kinase, cAMP response element-binding protein, and brain-derived neurotrophic factor (PKA-CREB-BDNF), thereby contributing to alleviating conditions of depression, anxiety, visceral hypersensitivity, and intestinal motility disturbances [71].