Frajese found that hydrogen-enriched electrolyzed water induced apoptosis in breast cancer cells and inhibited the expression of tyrosine kinase receptor 2 (ErbB2/neu), indicating that hydrogen-enriched electrolyzed water did not significantly affect the extracellular regulation of protein kinases (ERK1/2) and protein kinase B (AKT) [15]. The gene discussed is ERBB2; the disease is breast carcinoma.