The key roles of the COX-2/PGE2 pathway in CRC pathogenesis include generating an immunosuppressive tumor microenvironment [17], participating in tumor initiation, promoting sustained angiogenesis and thus favoring tumor growth, inducing tumor cell invasion, encouraging migration, reducing apoptotic rate and enhancing chemotherapeutic resistance [18,19]. Here, PTGS2 is linked to colorectal carcinoma.