This work aimed to evaluate the effect of standardized extracts and coumarins obtained from T. lucida in a model of chemically induced MS involving the chronic administration of cuprizone in BALB/c mice and quantifying neurological behavior with the Irwin test, motor impairment, neuroinflammation (IL-1β, TNF-α, IL-4, and IL-10), and vascular permeability in different organs (brain, kidneys, spleen). The gene discussed is TNF; the disease is myeloid sarcoma.