Like other G protein-coupled receptors, GPR35 has been shown to modulate signaling pathways that may be implicated in myocardial damage GPR35 was found to be positively regulated in the acute myocardial infarction phase and cultured cardiomyocyte hypoxia cell models (HL-1 and neonatal mice cardiomyocytes) [55]. The gene discussed is GPR35; the disease is myocardial infarction.