This complex interplay highlights the critical role of elevated SOD levels for individuals with IBD, as they often experience compromised cellular barrier integrity and subsequent increased intestinal permeability, allowing luminal antigens, such as pathogenic bacteria and their products, particularly lipopolysaccharide (LPS), to invade the previously sterile lamina propria and submucosa [38,39,40]. The gene discussed is SOD1; the disease is inflammatory bowel disease.