LEP and obesity due to melanocortin 4 receptor deficiency: Interestingly, triterpenoids with significant antitumor potential have not yet been evaluated as inhibitors of the pro-tumor activity of leptin, despite the proven ability of ursolic acid and escin to effectively suppress leptin-mediated processes in various non-tumor models, such as atherosclerosis [15] and high-fat diet-induced obesity [16], respectively.