LEP and neoplasm: Notably, despite the proven ability of leptin to promote the acquisition of epithelial-derived tumor cells by mesenchymal traits (induction of EMT) [29], in NC-derived neuroblastoma cells, this adipokine induced a shift of EMT markers towards an epithelial phenotype, as shown in Figure 2H. Despite this finding, the pro-mitogenic (Figure 2C), pro-migratory (Figure 2D), and adhesion-suppressive (Figure 2G) effects of leptin on Neuro2a cells clearly indicate its stimulating influence on neuroblastoma aggressiveness.