Although many attempts have been made to model PKAN disease in several organisms [38,78,79,80,81,82,83,84,85,86,87], they have not faithfully reproduced the main phenotypic alterations found in the disease such as brain iron overload and movement disorder symptoms, possibly because PANK2 localization in the intermembrane space of mitochondria has only been demonstrated in primates and humans. The gene discussed is PANK2; the disease is movement disorder.