However, other researchers have described a mitochondrial localization although a mitochondrial targeting sequence has not been identified in the mouse PANK2 enzyme [88,89]; In a PANK2 knockout mouse model, researchers found decreased weigh, retinal degeneration and azoospermia, but no movement disorders or signs of iron accumulation in the brain [82]. The gene discussed is PANK2; the disease is Azoospermia.