TP53 and cancer: Among these biological activities, the in vitro antiproliferative activity against cancer cell lines has been mostly reported, with it being associated with interfering with the activity of several mechanisms and targets related to carcinogenesis, namely aromatase, 17-β-hydroxysteroid dehydrogenase, proteasome, VEGF, MMP-2/9, JAK/STAT signaling pathways, CDC25B, microtubule (tubulin), cathepsin-K, topoisomerase-II, p53, and Wnt, among others [15,17,18].