Among them, chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) revealed potent growth inhibitory activity against human cancer cells (2.1 ≤ GI50 ≤ 3.4 μM and GI50 = 6.25 μM, respectively) through potential activation of p53 by disrupting its interaction with MDM2 and MDM2/X, respectively [21,23]. Here, TP53 is linked to cancer.