In contrast, for the three downregulated miRNAs, the top 10 enriched KEGG pathways were the hedgehog signaling pathway, Wnt signaling pathway, Hippo signaling pathway, circadian rhythm, cancer pathways, selenocompound metabolism, insulin signaling pathway, Th17 cell differentiation, cellular senescence, and spinocerebellar ataxia. Here, INS is linked to cancer.