MAPT and tauopathy: An age-dependent decrease in body weight is frequently reported in various tauopathy mouse models [14], including previously in the Tau58/2 line [24,26], and might—at least partially—be related to the observed decrease in hindlimb muscle diameter in the Tau58/4 model [27], which was also observed in a related tauopathy mouse model expressing the P301L mutation in tau (4R0N) [58], but also, wasting and metabolic alterations may underlie the weight loss.