Adamantylamine derivative demonstrated high activity against all tumor lines used, along with low cellular toxicity, while the 1-amino adamantane and (+)-myrtenal-derived compound 9 exhibited antitumor potential by inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) activity (IC50 6 μM), an important target for antitumor therapy, according to research by Ponomarev et al. (2018) [155]. This evidence concerns the gene TDP1 and neoplasm.