Glutamatergic signals may induce calcium transients through calcium-permeable AMPARs, activating downstream Akt-PKB pathways that promote GBM growth and invasion (Ishiuchi et al. (2002) [295]; Piao et al. (200) [296]; Venkatesh et al. (2019) [99]). The gene discussed is AKT1; the disease is glioblastoma.