Conversely, Huffels et al. revealed that in the APP/PS1 AD mouse model, dentate gyrus astrocytes in the proximity of Aβ plaques showed increased expression of Kir4.1 but regular function, possibly to compensate for increased extracellular K+ levels (Huffels et al. (2022) [42]). The gene discussed is KCNJ10; the disease is Alzheimer disease.