Cx43 can foster invasiveness by activating different pathways (i.e., by interacting with different cytoskeletal proteins) and also by promoting the transfer of oncogenic signaling molecules from tumor cells to neighboring astrocytes or among astrocytes (Sin et al. (2016) [107]; Uzu et al. (2018) [108]; McCutcheon and Spray (2022) [109]). The gene discussed is GJA1; the disease is neoplasm.