The role of Piezo1 in the context of AD has been studied in the 5xFAD mouse model, where Yoda1 administration reduced Aβ accumulation and improved synaptic function together with learning and memory, in contrast to selective Piezo1 KO in microglia that exacerbates AD pathology (Hu et al. (2023) [37]). Here, PIEZO1 is linked to Alzheimer disease.