Kv3.4 is upregulated in AD human brains and 6-month-old Tg2576 mice, suggesting a possible role in the development of AD (Angulo et al. (2004) [46]; Pannaccione et al. (2007) [47]; Boscia et al. (2017) [48]). Here, KCNC4 is linked to Alzheimer disease.