In the 5xFAD model, the authors clearly showed that the protective effect is mediated by microglia, but it has already been shown that astrocyte Piezo1 is upregulated around Aβ plaques in postmortem AD brains (Satoh et al. (2006) [258]; Velasco-Estevez et al. (2018) [259]). Here, PIEZO1 is linked to Alzheimer disease.