P2X7R expression is upregulated in microglia, both in AD post-mortem brains and AD mouse models (McLarnon et al. (2006) [59]; Martínez-Frailes et al. (2019) [60]), and in astrocytes from mice overexpressing human tau protein (MAPT P301S)(Jin et al. (2018) [61]) and APP/PS1 mice (Martin et al. (2019) [62]). Here, MAPT is linked to Alzheimer disease.