BEST1 and brain disorder: Astrocytes express a large number of anion-permeable channels, including voltage-dependent chloride channels (ClC1-3), volume-regulated anion channels (VRAC), Maxi-Cl- channels (MAC), and Ca2+-dependent Cl- channels like Bestrophin 1 (Best1), which are all involved in brain diseases (Verkhratsky and Nedergaard (2018) [1]; Elorza-Vidal et al. (2019) [167]).