In GBM cell lines, the activation of α7nAChRs and α9nAChRs has been shown to inhibit cell apoptosis via the EGFR/Akt pathway and the promotion of cell proliferation via the EGFR/ERK pathway (Khalil et al. (2013) [303]; Pucci et al. 2022 (2022) [91]). The gene discussed is AKT1; the disease is glioblastoma.