Moreover, neuronal hyperactivity results in the release of factors, such as brain-derived neurotrophic factor (BDNF) and soluble neuroligin 3 (NLGN3) (Venkatesh et al. (2015) [274]), that add support to glioma progression and facilitate the synapsing of neurons onto glioma cells (Goethe et al. (2023) [275]). This evidence concerns the gene NLGN3 and central nervous system cancer.