Similarly with tau-associated pathologies, when the pattern of tau pathology distribution is different between AD and other tauopathies, spreading of TDP-43 pathology in AD differs from that in FTLD and ALS [166,167] and detailed staging scheme for classifying TDP-43 pathology in AD has been recently developed [167]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.