MAPT and argyrophilic grain disease: It has been shown that intracerebral injection of human brain extracts containing various pathological tau (AGD, CBD, PSP, PiD, AD) into the brain of transgenic (AGD, CBD, PiD [28]; AD, CBD [29]) and non-transgenic mice (AGD, CBD, PiD [28]; AD, CBD, PSP [30]) led to the development of cell-type specific and morphologically distinct tau pathologies that phenocopy the corresponding tauopathies, while the injection of synthetic tau preformed fibrils did not seed endogenous tau aggregates [31].