BMPR2 and coronary artery disorder: Concerning the genetic implication of genetics in PAH-CHD patients, although APAH-CHD is an infrequent phenotype for BMPR2 variant carriers, the significant different BMPR2 mutation rate between PAH-CHD patients who develop PVD (pulmonary vascular disease) and PAH-CHD patients without PVD demonstrates that the genetic predisposing factor is an important component to evaluate in the process of PVD in PAH-CHD patients [20].