By using spirometry as a marker of pulmonary function in a large cohort of pediatric CF patients, Corvol et al. [105] were able to confirm previous data on adults with CF reporting a correlation between TGFB1 and lung disease progression; in particular, variants of the TGFB1 gene at position +869T/C resulted in a significant association with lung function reduction (Table 2). Here, TGFB1 is linked to lung disorder.