Regarding TLR-5, Blohmke et al. [92] studied the association among TLR5 polymorphism, rs5744168 (c1174 C > T), and FEV1 decline; they could not demonstrate a significant modifying effect due to this polymorphism on the mean FEV1 in adult and pediatric CF patients. This evidence concerns the gene TLR5 and cystic fibrosis.