It has been shown that multiple significant GWAS signals are located around the P4HTM gene: rs34762726 [8], rs1491985 [33], and 14 SNVs found in the Finngen study for pain, lower back pain, dorsalgia, and other dorsopathies (https://r8.finngen.fi/, accessed on 10 December 2022). This evidence concerns the gene P4HTM and skeletal system disorder.