In addition, the missense and truncating mutations of XCR1 were the main two types of genetic alterations: Y14Tfs*33 truncating alteration was the high-frequency mutation, which was detected in three cases of STAD (stomach adenocarcinoma), one case of COAD, and one case of UCEC; A33T/S alteration was an important site mutation, which was detected in cases of COAD, STAD, OV (ovarian serous cystadenocarcinoma), and UCEC (Supplementary Figure S3C). Here, XCR1 is linked to colon adenocarcinoma.