SETD1A and Axenfeld-Rieger syndrome: Other genetic variants have been occasionally reported in individuals with a clinical diagnosis of ARS or isolated ARA, including dominant variants in COL4A1 in multiple families [6,7], recessive variants in CPAMD8, ADAMTS17, and CYP1B1 reported in one family each [8,9], and dominant variants in histone methyltransferases SETD1A and KMT2F in one family each [10].