CRH and mental disorder: A study conducted with 661 total participants (19.6 ± 1.2 years old), 121 of whom had at least one Diagnostic and Statistical Manual of Mental Disorders-IV diagnosis, concluded that individuals with high AEA inhibitory tone (FAAH 385A allele carriers) and high corticotropin-releasing hormone (CRH) signalling (corticotropin-releasing hormone receptor type 1 (CRHR1) rs110402 A allele homozygotes) had the least temporal habituation of the basolateral amygdala, a neuroimaging associated with fear extinction [24].