TDP2 and cancer: We want to highlight that given the use of topoisomerase poisons in cancer therapy, and to a particularly high level in some cancers, the overlapping of Tdp1 and Tdp2 functions in our results suggest that Tdp1/Tdp2 could be valid targets for the search for effective Tdp1/Tdp2 inhibitors as drug prototypes to improve the effectiveness of treatment and to overcome tumor resistance to topoisomerase poisons.